Changes in the Head of the Femur in Children Suffering

In 1882 Phillipe Gaucher, in his thesis for M.D. of the University of Paris (“ D’epithelioma primitif de la rate: hypertrophie idiopathique de la rate sans leucemie “), described a new type of splenic tumour which he thought was an epithelioma; and in 1904 Brill and his collaborators described similar cases which at autopsy showed collections of cells (Gaucher cells) in the bone marrow. Junghagen, in 1926, made the first detailed report on the radiographic changes of bone in a three-year-old girl with Gaucher’s disease. The extent of infiltration of bone with Gaucher cells, which contain the lipoid kerasin, determines the particular radiological findings, which in some cases are extensive. Pick (1933) suggested that the predominantly